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Abstract

IMMUNOBIOCHEMICAL PARAMETERS AS DIFFERENTIAL FACTORS BETWEEN COLORECTAL CANCER AND ITS ASSOCIATION WITH INTESTINAL SCHISTOSOMIASIS

Samia A. Ahmed1, Manal A. Hamed1*, Omar S. Omar2, Abdelbaset A. El-Aaser3

1Therapeutic Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
2 Breast Cancer Clinic, Department of Surgery, Cairo University Hospital, Cairo, Egypt.
3Cancer Biology Department, National Cancer Institute, Cairo University, Egypt.

ABSTRACT

Objective: Schistosomal infestation has been implicated in the etiology of several human malignancies including colorectal cancer (CRC). While sufficient evidence supports a relationship between S. japonicum species and CRC, the evidence linking S. mansoni to CRC occurrence is meager. Therefore, the object of the present study is to evaluate certain biochemical parameters as diagnostic tools to differentiate between colonic carcinoma and colonic carcinoma associated with S. mansoni infection among Egyptian patients. Design and Methods: Patients with intestinal shistosomiasis, colonic cancer and bilharzial colonic cancer were enrolled in this study. The parameters under investigation are intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VACM-1), endothelial leukocyte adhesion molecule-1 (E-selectin), fibronectin (FN), alpha fetoprotein, IL-10 and nitric oxide (NO). Results: The results revealed significant increase (P<0.0001) in all parameters under investigation in case of bilharzial colonic cancer patients than in colonic carcinoma or in schistosomal infection alone. Conclusions: These parameters succeeded in serving as biomarkers to differentiate between the two malignant types and elucidated their role in colorectal cancer secondary to shistosomiais.

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