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Abstract

DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS OF VALSARTAN MATRIX TABLETS

B. Saraswathi*, M. Rajendar, K.Ranjeeth Reddy, K.Mayuri, D.Vijay Kumar

ABSTRACT

The objective of the present study was to develop a delayed release matrix tablets of Valsartan,an anti hypertensive drug. The delayed release tablets were prepared by direct compression and formulated using different drug and polymer ratios, formulations such as F1 to F9. Natural polymer like Guargum, Pectin and Cellulose were used.Compatibility of the drug with various excipients was studied. The tablets were evaluated and showed compliance with Pharmacopoeial limits. The optimized formulation(F1) on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity, drug content, invitro release studies and friability. All tablets but one exhibited gradual and near completion delayed release for Valsartan, and 98.75% released at the end of 20h. The results of dissolution studies indicated that formulation F1, the most successful of the study, exhibited drug release pattern very close to theoretical release profile.

Keywords: Valsartan, Guargum, Pectin,Cellulose, delayed release, Matrix Tablets.


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