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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SMALL MOLECULE ANTAGONIST FOR EGFR- A PRELIMINARY COMPUTATIONAL FRAMEWORK OF AZO DERIVATIVES AS THERAPEUTIC AGENT FOR BLADDER CANCER

K. Loganathan*, K. Sithick Ali, J. Gerad Rakesh A. Mohan, R. Thulasibabu,Rajani Gopal Gad , M. Purushothaman , S. Silambarasan, A. Jamal Abdul Nasser

ABSTRACT

Epidermal growth factor receptor (EGFR) is the well-established and iconic target for a variety of cancer types. The recent attractive molecular receptor identified is EGFR. Small molecule based drug discovery is the rapidly growing field wherein the design of therapeutics is the master approach till date. This study throws light on the series of azo derivatives from the one of our previous reports may evolve as the effective anti- EGFR agent. We worked with successful insilico approaches like molecular docking and pharmacokinetic properties. As a result, we found all the six azo derivatives are exceedingly capable of acting as antagonist for EGFR, further more we document that as molecule with therapeutic value in bladder cancer.

Keywords: Bladder Cancer, EGFR, Glide, ADME.


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