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Abstract

ENHANCEMENT OF DISSOLUTION RATE OF OXCARBAZEPINE BY USING VARIOUS SOLID DISPERSION TECHNIQUES

Madhu Gudipati*, Prathibha Bharathi Chittem and Rama Rao Nadenlla

ABSTRACT

Oxcarbazepine is an anticonvulsant drug, mainly used as an add-on or first line treatment in adults and children. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouth-dissolving tablets of oxcarbazepine, which offers a new range of product having desired characteristics and intended benefits. The aim of this research wok is to formulate and evaluate Oxcarbazepine solid dispersions system by using the different techniques. This will increase the solubility of the drug or Oxcarbazepine and give the immediate release of the drug from the formulations. In this study, the mouth dissolving tablets were prepared using three different technologies like Physical mixing, solvent evaporation and Kneading techniques. The disintegrating agent used in the present study is Croscarmellose sodium. Solid dispersions of oxcarbazepine with Croscarmellose sodium in different weight ratios were prepared with a view to increase its water solubility. Oxcarbazepine solid dispersions with Croscarmellose sodium in 1:5 ratios of drug: carrier showed maximum drug release and hence, compressed along with other ratios into mouth dissolving tablet. Among the three different techniques used for preparation of solid dispersions Kneading method (KM) technique has shown the increase in dissolution rate that is the KM (III) was found to have a faster solubility and dissolution property which was prepared by using Croscarmellose sodium as a disintegrant in the ratio of 1:5. KM (III) which is prepared by using drug and disintegrant ratio of 1:5 ratios by using Kneading method (KM).

Keywords: Oxcarbazepine; Mouth dissolving tablets; Solid dispersions; Croscarmellose sodium; Physical mixing; solvent evaporation and Kneading techniques; Dissolution rate.


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