HOMOLOGY MODELLING AND DOCKING STUDIES OF PHYTO COMPOUNDS FROM TRIGONELLA FOENUM GRAECUM FOR ANTI DIABETIC ACTIVITY
Sabreen Ali Mohammed , Manjunatha S, Dase Gowda KR, HemanthPhanikumar Sudhani, Maruthi Prasad E*,Lakshmi Devi Kodidhela
Diabetes mellitus is a most common endocrine disorder, affecting more than 300 million people worldwide. For this, therapies developed along the principles of western medicine (allopathic) are often limited in efficacy, carry the risk of adverse effects, and are often too costly, especially for the developing world. In order to identify complementary or alternative approaches to existing medications, we studied the anti-diabetic potential of Trigonella foenum-graecum active compound (TFGA).Î±-glucose inhibitors (AGI) are a group of compounds which inhibit the rate of breakdown of dietary oligosaccharides, polysaccharides. This delays the glucose absorption. Acarbose, miglitol and voglibose are different AGIs, but only acarbose is available for clinical use while miglotol and voglibose are under clinical investigation. Based on previous literature, we selected some of the Phyto-compounds of T. foenum-graecum(2- propen-1-amine-trimethyl-, trans- Nethylprop- 2-en-1-amine, 1- Azabicyclo octane,4-methyl 7-methyl-4-azatricyclo nonane, 3- o-Methyl-d-glucose 2,3,4,5,6-pentahydroxyhexanal, Dibutyl phthalate dibutyl phthalate, Heptanoic acid, 2-ethyl 2-ethylheptanoic acid, Hexane, 3-bromo 3-bromohexane, 1- Dodecyne dodec-1-yne, Aziridine, 1,2,3-trimethyl-,trans-1,2,3-trimethylaziridine, Pentanal 2-methyl 3-methylpentanal, Didodecyl phthalate, 9,12-Octadecadienoic acid (z, z)-, phenylmethyl ester, D-glucopyranoside, methyl 2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol) through docking studies with Î±- Glucosidase modeled protein and the active compound was found 3-o-Methyl-d-glucose 2,3,4,5,6-pentahydroxyhexanal (TFGA).
Keywords: Diabetes mellitus, Docking studies, Trigonella foenum graceum, aglucosidase.
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