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Abstract

ANTIBACTERIAL AND ANTIFUNGAL STUDIES OF 5-ACETYL-4- ARYL-6-METHYL-3, 4-DIHYROPYRIMIDIN-2(1H)-ONES

D.Devanathan* and S. Chitra

ABSTRACT

Eight 5-acetyl-4-aryl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones 4a-h are prepared and screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella typhi and antifungal activity against Candida albicans, Aspergillus flavus, Rhizopus and Mucor. Compounds 4d-h exhibited excellent in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Whereas the same set of compounds exerted potent in vitro antifungal activity against Candida albicans and Aspergillus flavus.

Keywords: Dihydropyrimidinones, antibacterial activity, antifungal activity, Synthesis.


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