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Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE MUCOADHESIVE MATRIX TABLET OF NADOLOL

J.Gomathi, Palanisamy.P, Loganathan, B.Jaykar

ABSTRACT

present study we have studied the feasibility of preparing mucoadhesive buccal delivery systems containing Nadolol to improve drug residence time on buccal mucosa and drug dissolution rate, to circumvent the first-pass metabolism and quick drug entry into the systemic circulation. Bilayer buccal tablets of nadolol were prepared by direct compression method using combination of polymers (such as HPMCK4M, and along with Carbopol934P). Eight formulations were developed with varying concentrations of polymers. The designed tablets were evaluated for various physical and biological parameters like hardness, weight variation, %friability, thickness, drug content uniformity, in-vitro drug release, stability studies, drug-excipients interaction (FTIR). Among the eight formulations, the formulation F2 containing Carbopolā€934P and HPMC K4M in the ratio of (2 : 4) showed good mucoadhesive strength (36.8) was found to be promising. Cumulative drug release data revealed that nadolol formulation F2 was found to be 96.80% in 12 h. Stability studies on the promising formulation indicated that there are no significant changes in drug content and in vitro dissolution characteristics (p < 0.05). FTIR studies show no evidence on interaction between drug and excipients. The present study proves that mucoadhesive bilayer tablets of Nadolol with controlled drug release properties can be successfully prepared by direct compression method using HPMCK4M, and along with Carbopol934P. The prepared buccal tablets of Nadolol were able to stay in the buccal cavity for a longer period of time, which indicates a potential use of mucoadhesive tablets of Nadolol for treating blood pressure.

Keywords: Mucoadhesive buccal tablet, Swelling index, Nadolol, Sodium CMC, HPMCK4M, Carbopol934P.


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