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Abstract

ECLIPTA PROSTRATA L.: ANTIBACTERIAL AGENT AGAINST MULTIPLE DRUG RESISTANT (MDR) PATHOGENS ISOLATED FROM CLINICAL SPECIMEN

Durgesh D. Wasnik* and P.M. Tumane

ABSTRACT

The present study was carried out for evaluation of antibacterial activity of Eclipta prostrata L. against multiple drug resistant (MDR) bacteria isolated from clinical specimen. The antibacterial activity of Eclipta prostrata L. were evaluated on MDR strains such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, Salmonella spp., Enterococcus faecalis, Citrobacter freundii, Acinetobacter baumannii, Streptococcus pneumoniae, Enterococcus faecium and Enterobacter cloacae. Antibacterial activity of five different solvent extracts (Methanol, acetone, ethanol, petroleum ether and n-Hexane) were prepared by using Soxhlet extractor. In-vitro antibacterial activity was performed by agar well diffusion method. The phytochemical anyalsis showed that the presence of Saponins, Glycosides, Alkaloids, Flavonoids, Phenolic substance Di & Tri-terpenes and Steroids in both methanolic and ethanolic extracts. The ethanolic and methanolic extract showed good inhibitory activity against all tested bacteria. The methanolic extract showed highest zone of inhibition against S. typhi (20 mm), P. mirabilis (19 mm), S. aureus (18 mm), K. pneumoniae (18 mm), E. coli (17 mm) and P. aeruginosa (16 mm). The lowest MIC value of methanolic extract was found against E. coli, S. typhi, A. baumannii and E. faecium (6.25mg/ml) and highest MIC value was found 12.5 mg/ml against remaining bacteria. The ethanolic extract showed zone of inhibition against S. pneumoniae (18 mm) followed by P. mirabilis (18 mm), S. aureus (16 mm), S. typhi (16 mm), E. coli (14 mm), K. pneumoniae (14 mm) and C. freundii (14 mm). The lowest MIC value was observed against 12.5mg/ml and highest MIC value was 25mg/ml against tested bacteria. Acetone extract also showed good inhibitory activity against tested bacteria. The maximum zone of inhibition was found against S. pneumoniae (15 mm) after that S. aureus (14 mm), P. aeruginosa (14 mm),S. typhi (14 mm) and C. freundii (14 mm).

Keywords: MDR, Antibacterial Activity, Eclipta prostrata L., Soxhlet extractor.


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