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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE ANTISPASMODIC PELLETS

B. S. Venkateswaralu*, B. Jaykar, N.K.K. Sreedharan, Palanisamy.P, T.V. Narayana

ABSTRACT

Antispasmodic agents are used in the treatment of Irritable bowel syndrome (IBS). The formulation of antispasmodic agent in pellet, is to improve its oral bioavailability and possibility to restrict its absorption at colon, pellets were prepared by drug layering technique in three trails (T1 – T3), and further Four formulations (F1 – F4) were prepared with varying concentration polymers such as Eudragit S100, Eudragit L100 D55, Eudragit NE 30 D with suitable plasticizer. These formulations were subjected to various evaluation parameters like microscopic evaluation, flow properties, particle size distribution, assay and In-vitro drug release. In vitro release of the Formulation F4 was to optimized formulation, it posses to similarity factory with in Innovator products.

Keywords: IBS, Eudragit S100, Eudragit NE 30 D, Eudragit L100D 55, plasticizer.


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