WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

“FORMULATION, DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF PRASUGREL HYDROCHLORIDE”

R. Margret Chandira*, P. Palanisamy, B.Jaykar, A.Pasupathi, N. K. K. Sreedharan, Debjit Bhowmic

ABSTRACT

The aim of present investigation wss to develop immediate release formulation of Prasugrel Hydrochloride for oral drug delivery by using suitable concentration of superdisingrants. Croscarmellose sodium (AC-DI-SOL), povidone, MCC, Magnesium stearate was used to formulate the immediate release tablet. Croscarmellose sodium was used as superdisintegrant and povidone was used as a binder to control the release of drug. Special care was taken for Prasugrel Hydrochloride processing in low humidity condition and geometric mixing is applied to avoid content uniformity and segregation. The flow properties of the powdered blend for all the batches were found to be good and free flowing. The weight variation, hardness and friability of all the formulated tablets within the specified requirements. The disintegration times for the formulated tablets are within the range of USP. For Prasugrel Hydrochloride tablets direct granulation was method of choice. Results found that release profile of batch no.F6 matches with Innovator product. The Percentage cumulative drug release of batch. No. F6 was found at 30 Minutes 103.12%.

Keywords: Prasugrel Hydrochloride, Immediate release, Croscarmellose sodium, povidone.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More