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*Dr. Jiteksh Jain, Dr. J.P. Verma, Dr. Narinder Singh, Gaurav Bilwal,
Dr. P.Hemantha Kumar


A fracture is a break in the continuity of bone or cartilage or both. Bone fracture healing is a spontaneous, natural, complex, biological process. In Ayurvedic classics many drugs are advocated for enhancing fracture healing, Asthisamharadi churna is one of them. An experimental study was planned to evaluate the effect of Asthisamharadi churna on fracture healing in Wister rats. The study was conducted on 30 male albino wister rats (Rattus Norwegicus) age of approximately 12 weeks. Before starting the trial toxicological study was accomplished. After 1 week of adaptation, all rats were given left radial open transverse osteotomy under aseptic conditions. The rats were evenly, randomly divided into three groups. Group I was intervened with trial drug 270 mg/kg body weight twice daily dissolved in godugdh (cow milk) and goghrita given according to body weight of rat through oral route, in group II with double dose of trial drug and in group III no drug was given. Group III animal were administered only godugdh and goghrita twice daily in order to avoid biasing concerning diet and handling stress. The treatment was carried out for four weeks. The blood samples were taken directly from orbital puncture technique for bone specific alkaline phosphatase analysis before and during the trial. Digital X-Ray was taken on 2nd, 3rd and 4th week during trial period. The bone fragments of euthanized rats were taken on the last day of trial for histopathology. Study shows that the levels of bone specific alkaline phosphatase (BsALP) in the osteoblast line cells and bones are proportional fracture healing. The study conclude that drug “Asthisamharadi Churna” augment the fracture healing process and was found to have slightly better outcome in group II when compared against group I and control group.

Keywords: Asthisamharadi churna, Bhagna, Fracture, Fracture healing, BsALP activity.

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