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Abstract

PROTECTIVE EFFECT OF MELIA AZEDARACH ON NICOTINE INDUCED CHANGES IN REPRODUCTIVE TISSUE OF FEMALE ALBINO RATS

*K. Bhuvaneswari and V. Elango

ABSTRACT

The beneficial effects of Melia azedarach extract as an antioxidant has been assessed in nicotine administered rats to examine the effects of nicotine on the antioxidant defense systems in reproductive tissue of female albino rat. The rats were divided into 4 groups. Group I: control animals received normal saline, Group II: injected with nicotine 4mg/kg, Group III: injected with nicotine4mg/kg and Melia azedarach 100mg given orally. Group IV: given Melia azedarach 100 mg/kg orally. The experimental group were injected subcutaneously 4 mg/kg of nicotine tartrate daily for 30 days. The animals were sacrificed after 24 hours after the last treatment by cervical dislocation and isolated the ovaries and uterus tissue washed with ice-cold saline and stored 40c at for enzymatic assays. In the present study Glutathione (GSH) vitamin E, vitamin C and vitamin A nicotine treated rats in the reproductive tissue and enhancement was observed in the combination treatment (Nicotine+ Melia azedarach ).The data obtained from this study speculated that 100 mg of Melia azedarach has the capacity to scavenge free radical and can protect against oxidative stress induced by Nicotine intoxication. Supplementation of Melia azedarach could be useful in alleviating antioxidant enzymes in nicotine induced reproductive tissue injury in female rats.

Keywords: Nicotine, Melia azedarach, Glutathione (GSH) ,vitamin E, vitamin C and vitamin A


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