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Abstract

ALISKIREN RETARDS THE PROGRESSION OF RENAL DISEASE IN DIABETES MELLITUS: AN EXPERIMENTAL STUDY IN RATS

Bassim I Mohammad1, Zahraa Abdul Kareem2, Najah R Hadi3, *Hayder A Al-Aubaidy4

1College of Pharmacy, University of Al Qadisiyah,Iraq
2Departmentof Pharmacology, College of Pharmacy,Karbalaa University,Iraq
3Departmentof Pharmacology, College of Medicine,University of Kufa, Iraq
4Biomedical Science Discipline Leader, Health and Rehabilitation Course Coordinator, School of Community Health, Centre for Research in Complex Systems, Charles Sturt University, NSW, Australia.

ABSTRACT

Objective:This study was undertaken to evaluate the protective effect of aliskiren on renal disease progression in diabetes mellitus. Materials and methods: Twenty-one adult albino rats were randomly divided into 3 groups: the normal control group (NC) injected with citrate buffer,the diabetic control group (DC)injected with streptozotocin (STZ) (60mg/kg I.P), andthe aliskiren treated group (AT),injected with STZ (60mg/kg I.P) and received aliskiren (10 mg/kg orally daily for 8 weeks).At the end of 8th weeks, blood& urine samples were collected for measurements of random blood sugar (RBS), HbA1c, renal function parameters,malondialdehyde (MDA) and reduced glutathione (GSH). Monocyte chemoattractant protein-1 (MCP-1) and histopathological assessment of degree of renal damage also performed. Results: Compared to DC group, there is a significant decrease in the levels of blood urea (40.12.31), uric acid (4.130.191), serum creatinine (0.890.074), albuminuria (27.42.03), andMDA(1.210.013) in the ATgroup,(p≤0.05). Expression of renal MCP-1 significantly decreased associated with a significant reduction in glomerular lesion in AT group compared to NC group (p<0.001). Conclusion: We concluded that aliskiren is helpful in reducing lipid peroxidation, improvingrenal function and reducingrenal expression of inflammatory markers and consequently reduces the progression of diabetic nephropathy.

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