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Abstract

DEVELOPMENT OF ORAL FORMULATIONS FOR COLONSPECIFIC DRUG DELIVERY USING EUDRAGIT, HPMC AND CARBOPOL AS EXCIPIENTS

Rajneesh Kumar* and Dr. Awani Kumar Rai

ABSTRACT

The aim of present research work was to develop colon targeted controlled drug delivery system of mesalamine tablet by using slight modification in CODESTM technology that protect drug during its passage through the stomach and about first six meters of small intestine. Method: The drug and polymers were directly compressed in tablet press. Mesalamine tablets were prepared in two group A and B. In group A tablets with combination of carbopol with HPMC and in group B alone carbopol were used. Tablets were spray coated with lactulose USP solution then followed with acid-soluble coating material, eudragit E-100 (10%w/w), water-soluble HPMC (10%w/w), enteric-coating material, eudragit L-100 (10%w/w). Mesalamine core and coated tablets were characterized with official methods. No in-vitro release of mesalamine in pH1.2 for first hour and in buffer pH 6.8 for next four hour but in PBS (phosphate buffer saline) pH 5.0 drug releases was observed. Result: in Group A the value of regression coefficient for batch CT-1 and CT-2 was 0.9978 indicating zero order release and in group B the value of regression coefficient for formulation R3 was found to be 0.9935 indicating zero order release.

Keywords: CODESTM technology, mesalamine, IBD.


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