WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF METOPROLOL SUCCINATE

Kube Rahul S.*, Kadam V. S., Shendarkar G. R., Bharkad V.B., Jadhav S.B.

ABSTRACT

Metoprolol succinate, β1- selective adrenergic receptor- blocking agent used in the management of hypertension, angina pectoris, cardiac arrthymias, myocardial infarction, heart failure, hyperthyroidism. In present investigation an attempt was made to reduce the frequency of dose administration to prevent nocturnal attack and to improve the patient compliance by developing to a sustained release formulation of Metoprolol succinate, the tablet was prepared by the direct compression method using different polymer with different concentration Ethyl Cellulose, HPMCK4M. Metoprolol Succinate and polymer compatibility interaction was investigated by using FTIR spectroscopy and DSC. The powder blends evaluated for precompression parameter, and tablet were subjected to post compression parameter. Also in vitro release studies upto the 12 hrs. Mathematical model in which Zero order, Higuchi model, First Order, Korsmeyer-peppas model. Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The release kinetic of the optimized formulation F5 followed by Higuchi model and non fickian transport. Design the sustained release matrix tablet formulation of Metoprolol succinate and elucidate the release behaviour was most successful formulation of the study using direct compression process.

Keywords: Sustained Release Metoprolol Succinate, Ethyl Cellulose HPMCK4M, Direct Compression and Mathematical model.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More