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Abstract

TO EVALUATE THE SAFETY AND EFFICACY OF ETIZOLAM AS ADD ON THERAPY WITH NAPROXEN SODIUM IN AN ACUTE TREATMENT FOR EPISODIC TENSION TYPE OF HEADACHE

Suman bala*, Yashpal singh, Dinesh K Badyal, Neeraj K Agrawal , Saurabh Kohli and D.C Dhasmana

ABSTRACT

Nonsteroidal anti-inflammatory drugs (NSAIDS) are used for acute treatment of episodic tension type headache(ETTH).Benzodiazepines are also commonly used for the treatment of TTH, however, there were very few randomized controlled trials (RCTs) recommending the use of these drugs. This study was undertaken to evaluate the safety and efficacy of etizolam in combination with a non-steroidal anti-inflammatory drug as an acute treatment of ETTH. Methods: We had included 60 patients diagnosed as per criteria of the International Classification of Headache Disorders-II. Patients were randomized into two groups: NSAID alone (naproxen sodium 250 mg) and NSAID plus etizolam (naproxen sodium 250 mg, etizolam 0.5mg) for the management of acute episode of tension type of headache. Improvement in Visual Analogue Scale (VAS) at two hrs of administration of drugs was the primary end point in this study. Changes in four-point verbal functional impairment scale at the base line and at the end of 2hr and reported adverse effects were also recorded. Results: Both groups showed a significant fall in Visual analogue scale for headache, four point verbal functional scales. The group receiving etizolam along with NSAID showed better response rate than NSAID alone .There was no significant difference in adverse effects between the groups. Conclusion: Combination of NSAID and Etizolam is useful and safe for the management of acute episode of ETTH.

Keywords: Headache, ETTH, etizolam, NSAIDS.


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