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Abstract

A COMPARATIVE STUDY OF ANALGESIC EFFECT OF TINOSPORA CORDIFOLIA WITH PIROXICAM IN ALBINO RATS, USING DIGITAL ANALGESIOMETER

Lakshmi Deepika P*, Dr. Supriya Priyambada,Dr. Jagadeesh P, 4Hanumanth N

ABSTRACT

Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain is frequently classified as physiologic or acute pain and pathologic or chronic pain, which includes inflammatory pain and neuropathic pain. Acute pain typically has a sudden onset and recedes during the healing process. Acute pain can be considered as „good pain‟ as it serves an important protective mechanism like withdrawal reflex. Chronic pain can be considered as „bad pain‟ because it persists long after recovery from an injury and is often refractory to common analgesic agents.Analgesics are the drugs which possess significant pain relieving properties by acting in the CNS or on the peripheral pain receptors without significantly affecting consciousness. Piroxicamis an NSAID (non-steroidal antiinflammatory drug) that is commonly used for the relief of symptoms of osteoarthritis and rheumatoid arthritis, primary dysmenorrhea, postoperative pain and act as an analgesic, especially where there is an inflammation component.Tinosporacordifolia (Guduchi) is a large, glabrous, perennial, deciduous, climbing shrub of weak and fleshy stem found throughout India.Tinosporacordifolia (T. cordifolia, Menispermaceae) belongs to a group of medicinal plants that grows in the tropical and subtropical regions of India. It has both analgesic and anti-inflammatory activity.The main aimof this study is tocompare the analgesic effect of Tinosporacordifolia with a standard analgesic drug Piroxicam. Objectives: To study the analgesic effect of Tinosporacordifolia, To compare the analgesic effect of Tinosporacordifolia with a standard analgesic drug Piroxicam. Materials & Methods: A Randomized controlled trail was conducted in the Dept. of Pharmacology, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation (Dr.PSIMS), Chinoutapalli, Krishna District, Andhra Pradesh with the institutional ethical committee clearance. Total rats were divided into 3 groups consisting of 6 rats in each group. First group of rats (control group) were treated with 0.2 ml normal saline. Second group were considered as standard group and treated with Piroxicam (standard drug) at dose of 0.33mg/kg. Third group were considered as test group and treated with Tinosporacordifolia(test) at dose of 100mg/kg which is the standard analgesic dose Conclusion:The result showed that Tinosporacordifoliais having analgesic property, and it is less when compared to Piroxicam. However the above preclinical experiments only give us an idea about the analgesic effect of Tinosporacordifolia&Piroxicam but large scale clinical trials are necessary for final assessment.

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