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Saikh Mahammed Athar Alli

Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shiats (Deemed to be University), Allahabad-221 007, Uttar Pradesh, India.


For have handy reference on the development of nanovesiclular oral delivery system of macromolecules (NvODSM). Biopharmaceuticals of macromolecule origin (viz. proteins, peptides, monoclonal antibodies, and vaccines) explored to deliver associated proclaimed benefits. Interest evoke for presenting them as oral delivery system while synergising their effect through amalgamating nanotechnology. This abreast increases efficacy, specificity, tolerability and therapeutic index, and minimises toxicities. Amongst several nano-systems nanovesicles provide improved performance, stability, and patient compliance. They are receiving attentions and have potential for marketability. Their development and design is progressed to make best formula through method of optimisation. Which considered being a state of art involves multidisciplinary activity and creates troubles. Available literature unable to provide information on combating issues relating their development while some remains unhandy. In this context, information collected and presented as handy note which will be a helping hand and will offer an outstanding knowledge. This article features on combating issues relating development of NvODSM and has applicability in product evolution, with excellent feature.


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