WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

BUTACHLOR INDUCED OXIDATIVE AND HORMONAL IMBALANCE CORRELATED WITH OVARIAN ANOMALIES IN FRESH WATER INDIAN CAT FISH CLARIAS BATRACHUS (LINN.): SEM STUDY

Prakriti Verma* and G. B. Chand

ABSTRACT

Fresh water Indian cat fish Clarias batrachus (Linn.) were exposed to Butachlor 2 chloro-N-(2-6 diphenyl) acetamide exposure at a dose of 1.5μl/L for 5, 10 and 15 days respectively. At the termination of each exposure blood samples were collected and analysed for serum Lipid peroxides (LPO), reduced glutathione (GSH), Thyroid stimulating hormone (TSH) and Estradiol level as per standard method of WHO. The ovarian tissues were fixed in chilled (4ºC) 2.5% gluteraldehyde followed by its post fixation in 1% OSO4 in 0.1 M Phosphate Buffer at pH 7.2. The tisssues were further processed for SEM studies. The results showed a significant (p<0.01) increase in LPO level and simultaneous decrease in GSH level of fish. A significant decrease in serum TSH and significant (p<0.05) increase in serum estradiol were reported. Ultra structure of ovarian cells showed grooves, papillae and protuberances on the surface of the oocytes. Hence it can be concluded that butachlor sets in a wave of oxidative and hormonal imbalance leading to gonadal atrophy in fish.

Keywords: Butachlor, Clarias batrachus, Estradiol, GSH, LPO, Ovarian tissues, SEM, TSH.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More