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Abstract

A VALIDATED RP-HPLC METHOD FOR ESTIMATION OF TELMISARTAN AND METOPROLOL IN ITS BULK AND PHARMACEUTICAL DOSAGE FORMS

*B. Thapaswini, T. Rammohan Reddy, A. Ajitha, V. Uma Maheswara Rao., S. Ramya Sri

ABSTRACT

Present work describes a simple, accurate, precise and reproducible
reverse phase High Performance Liquid Chromatographic method for
simultaneous estimation of Telmisartan and Metoprolol in bulk and
tablet dosage form on C18 (4.6×250mm) 5μ, with mobile phase
comprising of mixture of buffer Methanol: Water adjusted the pH3.5
with OPA (58:42% v/v), at the flow rate 1ml/min. The detection was
carried out at 224nm.The retention time for Telmisartan and
Metoprolol was found to be 2.09 and 5.08 min. respectively. Detection
response for both Telmisartan and Metoprolol were found to be linear
low in concentration range of 8-40 μg/ml and 5-25 μg/ml respectively
in the linearity study, regression equation and coefficient of correlation
for Metoprolol and Telmisartan were found to be (y = 7625x +927.0 ,
r2 =0.9999) and (y = 2922x – 1704, r2 = 0.9999). Proposed method was
validated for accuracy, precision, linearity, range, ruggedness &
robustness.

Keywords: Metoprolol, Telmisartan, RP- HPLC method; PDA detection; Tablet dosage forms.


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