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Abstract

LIVER AND METABOLISM

Mir S Adil*1, Muzammil Hassan2, Azizullah G3, Amer K1, M Maazuddin1, M Omer1

1Pharm.D, Deccan School of Pharmacy, Hyderabad –01, A.P.
2Pediatrician, M.B.B.S., DCH, Princess Esra Hospital, Hyderabad, A.P.
3M.Pharm, Deccan School of Pharmacy, Hyderabad –01, A.P.

ABSTRACT

Liver is the paramount organ for maintaining the body’s internal environment. There is currently no way to indemnify for the absence of liver function. Its major influence is on the flow of foreign particles and controls the metabolism of drugs and nutrients. As most drugs are taken orally these are the important substances which are passed through liver for first pass metabolism, thereby converting into metabolites which are compatible with the human body. The present review is to provide an understanding on the drug metabolism by the liver. Classification of drugs based on their hepatic extraction and the working of cytochrome P450 enzymes is also elucidated. Certain substances induce or inhibit the metabolism of some drugs, which may lead to sub-therapeutic drug concentration and toxicity respectively. This review can be helpful to figure out the mechanism for diversification in drug metabolism.

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