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Abstract

A REVIEW ON GYMNEMA SYLVESTRE A MAJOR ANTIDIABETIC ASCLEPIADACEAE HERB

Jyothi Chaitanya Pagadala*, Dhatri Madduru, Aparna Satya Deepthi Tadepalli

ABSTRACT

Gymnema sylvestre (Family- Asclepiadaceae), popularly known as
gurmar or Madhunashini. It is one of the most important medicinal
plant in India. It is a slow growing, perennial, medicinal woody
climber grows in Deccan Peninsula and widely distributed in Asia,
tropical Africa, Malaysia and Srilanka. It is well known for the
treatment of diabetes for over 2000 years in Indian Ayurvedic system
of medicine. The major chemical component of Gymnema sylvestre is
gymnemic acids which has antidiabetic, anti sweetener and antiinflammatory
activities. Traditionally Gymnema is used for treatment
of glycosuria and urinary disorders. The leaves are also used as
diuretic. Gymnema is propagated through seeds and stem Cuttings for
commercial cultivation in India. In Gymnema, many genetic variation
studies were done. It is also used in the treatment of asthma, eye
complaints, inflammations, family planning and snakebite. In addition to this it possesses
antimicrobial, antihypercholesterolemic, hepatoprotective and sweet suppressing activities. It
also acts as feeding deterrents to caterpillar, Prodenia eridania, prevent dental caries caused
by Streptococcus mutans and used in skin cosmetics. Recent reports suggest that Gymnemic
acid formulations have been found useful against obesity. It also has anti cancer activity
which was tested using biofunctionalized Silver and gold nanoparticles derived from aqueous
leaf extracts of G. sylvestre.

Keywords: Gymnema sylvestre, antidiabetic, leaves, antimicrobial, silver and gold nano particles.


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