WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND OPTIMIZATION OF MOUTH DISSOLVING TABLETS OF CANDESARTAN CILEXITIL BY LYOPHILIZATION METHOD USING SKIMMED MILK

Gurpreet Saini* and Dr. Sandeep Kumar

ABSTRACT

Hypertension , congestive heart failure have become most serious and common problems in today’s world. There are many dosage forms available but bed ridden, mentally ill and patients suffering from dysphagia suffers lots of problem in taking such conventional oral dosage forms .The present investigation was undertaken to formulate mouth dissolving tablet of Candesartan cilexitil which could solve most of the problems and provide good patient compliance with faster onset of action..To increase solubility and dissolution, solid dispersions of candesartan were prepared by lyophilization technique using TBA (tertiary butyl alcohol) as co-solvent .Skimmed milk was selected as carrier due to its taste masking , low cost and biocompatibility properties. Solid dispersions were prepared in ratios 1:3, 1:5, 1:7, 1:9. Solubility and in vitro studies showed better results for 1:5 (SD 2) and was selected for further studies .Drug polymer interaction was investigated by XRD and FTIR studies. Precompressional and post-compressional parameters were within prescribed limits and indicated good flow properties of powders.. To construct a statistical model, 32 full factorial design (FFD) was selected wherein camphor and crospovidone were selected as independent variables and disintegration time, friability were selected as dependent variables. Results indicated that optimized tablet provide disintegration time of 35 sec and friability 0.86%.

Keywords: Candesartan cilexitil, Skimmed milk, Lyophilization, Camphor, Sublimation, mouth dissolving tablets.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More