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Abstract

FORMULATION AND OPTIMIZATION OF MOUTH DISSOLVING TABLETS OF FAMOTIDINE USING LYOPHILIZATION TECHNIQUE

Gurbir Sokhal* and Dr. Sandeep Kumar

ABSTRACT

Gastric acid secretion and duodenal ulcers are the common problems among the people. Although there are many oral dosage forms available but problem comes with the geriatric, pediatric, bed ridden, mentally ill patients suffering from dysphagia (difficulty in swallowing).Purpose of the present study was to develop mouth dissolving tablet of Famotidine which can be proved useful for patients and provide optimal patient compliance. Solid dispersion of Famotidine was prepared using PEG6000 as a polymer using lyophilization technique. Among the five ratios (1:1,1:3, 1:5, 1:7,1:9) SD2 i.e. 1:3 showed better results. Pre-compressional and post– compressional studies were performed which comes within prescribed limit .XRD and FTIR studies were done to check drug polymer interaction.32 full factorial design was used for optimization. Camphor and crospovidone were used as independent variables and disintegration, percentage friability were used as dependent variables for optimizing the results. Results of multiple linear regression showed that for obtaining rapidly disintegrating tablet with minimum friability optimum concentration of camphor and increased percentage of crospovidone is used. Contour plot, response surface plots were presented. Tablets were subjected to vacuum drying for sublimation of camphor to make them porous.

Keywords: Famotidine, PEG6000, Solid dispersion, Lyophilization technique,Mouth dissolving tablet, Optimization.


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