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Sanjay Batra*, Mahesh Kumar Kataria, Ajay Bilandi


Pioglitazone Hydrochloride is an oral anti-diabetic agent, which acts primarily by increasing insulin dependent glucose disposal. There is a need for sustained release Pioglitazone formulations, which overcome the various problems associated with the use of this drug in the prevention and treatment of diabetes. The floating tablets were prepared by wet granulation method. In the present work efforts have been made to develop floating drug delivery system for Pioglitazone Hydrochloride with hydrophilic and hydrophobic polymer in different ratios to achieve a sustained release for 24 hrs. The in vitro drug release profile of Pioglitazone hydrochloride tablets containing Ethyl Cellulose, Xanthan gum and Eudragit RS100 gave desired drug release profile. The tablets of all formulation were subjected to various physicochemical evaluation parameters such as thickness, diameter, weight variation, hardness, friability, drug content, in-vitro buoyancy lag time, total floating time, tablets density, swelling index and in-vitro dissolution study. The results of all these tests were found to be satisfactory within the prescribed limits. The formulations showed higher R2 values for zero order plots indicating that drug release followed zero order kinetics.

Keywords: Pioglitazone hydrochloride, Ethyl Cellulose, sustained release matrix tablets.

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