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Abstract

DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE PELLETS OF LOSARTAN POTASSIUM BY EXTRUSIONSPHERONIZATION TECHNIQUE

Viresh M. Sunke*, Vaishali M. Gambhire, K. N. Gujar.

ABSTRACT

The Losartan potassium is an angiotensin-receptor blocker (ARB), is used alone or with other agents to treat hypertension. Losartan potassium lower blood pressure by antagonizing the renin-angiotensinaldosterone system (RAAS).It has short plasma half-life, low absolute bioavailability. The objective of present work was to develop oral sustained release pellets of losartan potassium by extrusion– spheronization method, using hydrophilic hydroxyl propyl methylcellulose (HPMC), xanthan gum and carbopol polymer as rate controlling polymer. The pellets were evaluated for micrometric properties, surface morphology, drug content, in-vitro drug release and dissolution kinetic model. The drug-polymer interaction results suggested no interaction between drug and polymer. SEM photomicrographs of optimized batch of pellet formulation (L7) showed the uniform spherical surface. Formulation (L7) containing HPMC (5%) and Xanthan gum (15%) gives 13.36% release at the 2 hrs and 96.38% release at 10 hrs. The optimized formulation (L7) follows zero order drug release kinetic conforming sustained release over a period of 10 hours.

Keywords: Losartan potassium, Extrusion-spheronization, Pelletization, sustained release, in vitro drug release


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