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Abstract

SYNTHESIS, SPECTRAL STUDIES OF SOME IMIDAZO [2, 1- b][1,3,4]THIADIAZOLE DERIVATIVES AS A POTENT ANTIMICROBIAL AGENTS

Manvinder Kaur* and Amandeep Kaur

ABSTRACT

Heterocyclic compounds occupy a central position among those molecules that makes life possible. The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1, 3, 4 thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behaviour have gained more importance in recent grades. During the recent years there has been intensive investigation of different class of thiadiazole compound many of which possess pharmacological activities. Among of these compounds having 1,3,4- thiadiazole nucleus are known to exhibit unique anti-inflammatory, anti-analgesics, antimicrobial, anti-tumour, antifungal, antimicrobacterial, anticonvulsant, antidiabetic, antiviral activities. So, far modification of thiadiazole ring have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized thiadiazole possess important biological activities.

Keywords: Antimicrobial agents, 1, 3, 4- Thiadiazole, Imidazo thiadiazoles.


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