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Abstract

PERCENTAGES OF SOLUBLE AND INSOLUBLE PROTEINS IN DIFFERENT TYPES OF CATARACTOUS LENSES COMPARED TO TOTAL PROTEIN WITH PHOTOGARPHIC APPERANCE

Dr. Ajit V Pandya*

ABSTRACT

Epidemiological literature indicates that the prevalence of cataract is related to geographical location, climate and sun hours. Cataract is a multifactorial process in which many intrinsic and extrinsic factors act cumulatively. The percentages of soluble protein (SP) and Insoluble protein (ISP) with respect to total protein in different types of cataractous lenses. The lowest (14.05%) and highest (85.94%) value of SP and ISP respectively is found in Brown cataract. The highest (44.76%) and lowest (55.23%) value of SP and ISP respectively is found in CS-NS=PP type of cataract. A “heavy molecular weight aggregateâ€Â (HMW protein) with an apparent molecular weight in excess of 15 * 106 can be isolated from the water soluble proteins by gel filtration.

Keywords: proteins, NS-Nuclear sclerosis, PSC- Posterior sub capsular, CS- Cortical spoke, ISP- Insoluble proteins, SP- Soluble proteins.


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