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Abstract

SERUM PRO-INFLAMMATORY CYTOKINES LEVEL AND ADENOSINE DEAMINASE ENZYME ACTIVITY IN PATIENTS WITH TYPHOID FEVER IN NAJAF/IRAQ

*Dr. Najlaa A.Ali Al-Dahhan

ABSTRACT

In the current study,60 serum samples from patients with typhoid fever and control(50 healthy individuals) were collected during 2014 years and examined for the presence of ADA enzyme, IL-6, and IFN-α. The mean values of ADA enzyme in the serum of typhoid fever patients were significantly higher (52.2± 4.32) than that of the control group(12.3 ± 6.03). The mean concentration of serum IL-6 and TNF-α were also higher significant(P<0.001) in typhoidal patients than healthy control (30.41 ± 1.03 and 6.73 ± 3.62) and (72.35 ± 2.03 and 42.71 ± 4.12). According to the gender, ADA enzyme in male showed high(49.3 L/U) than female(42.5 L/U) with no significant variation(P> 0.05).Male appeared significant raised in the concentration of IL-6 andTNF-α (62.14 ,52.45) pg/ml than female(57.3 , 45.32) pg/ml.

Keywords: ADA enzyme, Typhoid fever, Pro-inflammatory cytokines,IL-6,IFN-?.


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