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*C.P.Rathod1, A.K Dhadwe2, K.G Patil3

1Department of pharmaceutics and pharmaceutical technology, School of Pharmacy, S. R.T.M. University Nanded, Maharashtra, India.
2Department of Pharmacology, Nanded Pharmacy College Nanded,
3RRKS’S institute of pharmaceutical Education and research, Bidar, India.


The demand for Orodispersible tablet (ODT) has been growing during the last decade especially for elderly and children who have swallowing difficulties. Sumatriptan Succinate is serotonin and is a 5- HT agonist used in treatment of Anti-migraine agents. Oral bioavailability of Sumatriptan Succinate is around 15% (oral) and 96% (s.c) and having half life 2.5 hrs. In present work an attempt has been made to prepare Orodispersible tablets of Sumatriptan Succinate with increased rate of dissolution may leads to increase bioavailability. In present work Orodispersible tablet of Sumatriptan Succinate prepared using sodium starch glycolate, Crosscarmellose sodium and crospovidone as Superdisintegrants by direct compression methods. The tablets prepared were evaluated for various parameters. Containing of croscarmellose sodium showed highest in vitro drug release of 93% within 30 min. DSC, NMR, 13CNMR & IR spectral analysis the pure drug characteristic absorption bands and formulations absorption bands have shown all most same range.

Keywords: Orodispersible tablet; Sumatriptan Succinate; Crosscarmellose sodium; Sodium Starch Glycolate; Crospovidone (Polyplasdone XL 10); Anti-migraine.

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