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Abstract

POTENTIAL EX-VIVO ANTIOXIDANT INVESTIGATIONS OF PARATHELYPTERIS BEDDOMEI LEAVES

Md. Reyad-ul-ferdous*, DM. Shamim Shahjahan, Md. Sabbir Ferdous, Md. Munirul Islam Tanvir, Shamsunnahar Sumi, Mohammad Nazmul Alam, Galib Ahsan, Arif Mohammed Saleh, Rajesh Barua, Md. Mahmudul Hasan

ABSTRACT

The crude methanolic extract of leaves of Parathelypteris beddomei and its different organic soluble partitionates were screened for total phenolic content, and free radical scavenging activity. The amount of total phenolic content differed in different extractives and ranged from 50.58 mg of GAE / gm of extractives to 266.38 mg of GAE / gm of extractives of leaves of P. Beddomi. Among all extractives of leaves of P. Beddomei the highest phenolic content was found in PESF (12.41 mg of GAE / gm of extractives) which is followed by CSF (11.20 mg of GAE / gm of extractives). Significant amount of phenolic compounds were also present in CTCSF (2.08 mg of GAE / gm of extractives). The phenolic contents were observed in lesser amount in ME (2.08 mg of GAE / gm of extractives) followed by AQSF (3.11 mg of GAE / gm of extractives). In this investigation, AQSF showed the highest free radical scavenging activity. The IC50 value was 0.36 μg/ml. The other partionates like PESF, CSF, CTCSF and ME exhibited good scavenging activity having IC50 values 62.31 μg/ml, 72.02 μg/ml, 8.51 μg/ml, and 5.31 μg/ml, respectively. Further studies may lead to isolation of potent drugs moieties from P. Beddomei.

Keywords: Parathelypteris beddomei; Biological Investigation, Total Phenolic Content, Antioxidant, DPPH.


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