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Abstract

THE EFFECTS OF SMOKING ON MICRONUCLEUS FREQUENCIES IN BUCCAL CELLS OF HEALTHY IRAQI INDIVIDUALS

Dr. Farha A. Ali Shafi*

ABSTRACT

The genotoxic damage that Tobacco smoke produces in smoker
individuals was evaluated using the micronucleus assay in exfoliated
buccal cells. The study comprises 90 individuals of which 46 were
smokers and 44 were nonsmokers. We found the mean of the
micronuclei frequency in exfoliated buccal cells was (10.18 ±
1.07;12.89±1.85) in nonsmoker and smoker individuals respectively,
which is substantially higher than the baseline of the micronuclei
expression in the general healthy population.There was a statistically
significant difference in the micronuclei expression between smokers
and non-smokers(P<0.05). The mean value of micronucluei frequency
in youngest age group (20-30)years was (14.27±1.63) ;in oldest age
group(31-40) it was (9.75 ±0.87),the difference was significant (P<0.01). We concluded that
the higher frequency of micronuclei directly associated with the decrease of efficiency of
DNA repair and increase of genomic instability. Micronucleus assay in the buccal cell is
sensitive, practical, inexpensive method for monitoring genetic damage in human. Further
researches are needed not only for count micronuclei but also to capture the frequency of
apoptosis and necrosis cells to detect the further evaluation of cellular and tissue level
biological damage.

Keywords: buccal cells, healthy, Iraqi, Micronucleus assay, smoking.


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