WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

MULTICENTRIC CASTLEMAN’S DISEASE: A PEER REVIEW

Chandrasekhar.CH, Achutha Lakshmi.P*, G.Sumalatha, V.Vasu,
S. Lakshmi Anusha, G.Uma Maheswari

ABSTRACT

Benjamin Castleman first described multicentric Castleman’s disease (MCD) in a series of cases in 1954. Interest in MCD has grown in recent years following an association with human immunodeficiency (HIV) infection. Castleman’s disease is a rare lymphoproliferative disorder in there has been recent p rogress in elucidating underlying mechanisms with potential therapeutic implications. Unicentric Castleman’s disease is an indolent condition that is often treated with local approaches. In contrast, patients with multicentric Castleman’s disease (MCD) have a less favorable prognosis and require systemic treatment. Cytotoxic chemotherapy, with its atten- dant risk for toxicity,has been widely used to treat MCD, with variable efficacy. The discovery of putative etiologic factors and targets in MCD, particularly human herpesvirus 8, CD20, and interleukin (IL)-6, has been translated into the use of rituximab and anti–IL-6- based therapy,,as well as antiviral agents.

Keywords: Castleman, multicentric Castleman’s disease, (HIV)infection.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More