WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND IN VITRO EVALUATION OF SUMATRIPTAN SUCCINATE FAST DISSOLVING TABLETS

P.S.A.Chakravarthy

Venkateswara Institute of Pharmaceutical Sciences, Andhrapradesh. India

ABSTRACT

Recent development in Fast disintegration tablets have brought convenience in dosing to elderly and children who have trouble in swallowing tablets. The objective of the present study was to prepare the Fast disintegration tablets of sumatriptan succinate, an anti migrane drug. As precision of dosing and patient compliance become an important prerequisite for a migrane treatment, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient's acceptability. Hence, the present work was undertaken with a view to develop a fast disintegration tablet of sumatriptan succinate which offers a new range of product having desired characteristics and intended benefits. Various techniques like direct compression and sublimation technique were used to formulate Fast disintegration tablets of sumatriptan succinate. In direct compression method and sublimation method the effect of various super disintegrants was studied, among these 4% cross povidone showed better drug release. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content. Optimized formulations were evaluated for in-vitro dissolution test. Amongst all the techniques sublimation technique was found to be most successful and tablets prepared by this technique (F12) had disintegration time of 30 sec. and % CR 52.741.42 after 5 min.

Keywords:


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More