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Abstract

A REVIEW ON EXTRACTION OF HERBAL DRUGS AND THE ENHANCEMENT OF SOLUBILITY BY HYDROTROPY TECHNIQUE

R.S. Pentewar*, Utikar M., Gaikwad S.S., S.S.Thonte, Manjusha Bhange, R. V. Sugave

ABSTRACT

Aqueous solubility of a therapeutically active substance is a key property as it governs dissolution, absorption and thus the therapeutic effects in-vivo. Recently more than 40% APIs (Active Pharmaceutical Ingredients) developed in Pharmaceutical Industry are practically insoluble in water. Formulation of poorly soluble compounds for oral delivery now presents one of the interesting challenges to formulation scientists in the pharmaceutical industry. Solubility can be enhanced by many techniques among them hydrotropy is of very much importance which enhance solubility to many folds with use of Hydrotropes like sodium benzoate, sodium citrate, urea, Niacinamide etc. and have many advantages like; it does not require chemical modification of hydrophobic drugs, use of organic solvents, or preparation of emulsion system etc. Hydrotropes are promising agents which have the ability to facilitate extraction process by enhancement the solubility. This review focuses the application hydrotropic agent that solubilises hydrophobic drugs especially in case of oral formulation solubility remains a critical factor and their use in extraction of herbal drugs by using hydrotropy Solubilization phenomenon. The main objective of the present review is to explore the possibility of employing a new inexpensive hydrotropic agent, to replace the use of an organic solvent and Hydrotropes such as sodium alkyl benzene sulfonates and sodium butyl monoglycol sulphate were used for the selective extraction of water insoluble phyto-constituents by cell permeabilization. Hence Hydrotropy is new, simple, economic, safe method, can be used in analysis and extraction of herbal drug.

Keywords: Hydrotropy, Urea, Extraction, Solubility enhancement.


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