WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

A NOVEL QUANTITATIVE ESTIMATION OF POORLY WATER SOLUBLE DRUG ATORVASTATIN BY USING HYDROTROPIC SOLUBILIZATION TECHNIQUE

D. Pardha Saradhi1*, T.Sivannarayana2, T. Govardhana chari3, A.Ramakrishna4, Sk. Abdul Rahaman5

1Pharmaceutical analysis, Nirmala college of pharmacy, Acharya Nagarjuna University, India
2Pharmaceutics, Nirmala college of pharmacy, Acharya Nagarjuna University, India
3Pharmaceutics, Nirmala college of pharmacy, Acharya Nagarjuna University, India
4Pharmaceutics, SIMS College of Pharmacy, Acharya Nagarjuna University, India
5HOD of Pharmaceutical chemistry, Nirmala college of pharmacy, Acharya Nagarjuna University, India

ABSTRACT

In the present research, hydrotropic solubility enhancement has been done helpful for soluble poorly water soluble anti hypertensive drug is atorvastatin. The hydrotropic substance is urea. This technique is reliable and simple. In the present study more than 2 folds solubility enhanced when compared to distilled water alone. The urea was used in different concentrations 10, 20,30,40,50 and 60mg. The drug and hydrotropic substance ratios were 1:1, 1:2, 1:3, 1:4, 1:5 and 1:6. The hydrotropic substance (urea) did not interfered in the analysis. The hydrotropic substances are freely available, less cost, pollutant free method. The hydrotropic solubility enhancement technique is very accurate, the solubility enhancement further helpful for improve bioavialabity of drug.

Keywords: Atorvastatin, Urea, Hydrotropic technique, Solubity enhancement.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More