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Abstract

FORMULATION AND EVALUATION OF FEXOFENADINE HYDROCHLORIDE AND PARACETAMOL CHOCOLATE FOR PEDIATRICS

*V.Viswanath, B. Narasimharao, M.Purushothaman, S.Sireesha

ABSTRACT

Chocolate is highly sophisticated and much adaptable food that can be combined to create completely different taste and consistency sensations. The objective of the present study is to develop a chocolate formulation of Fexofenadine hydrochloride and Paracetamol for pediatric administration. The formulation consists of developing a chocolate base containing a cocoa powder, cocoa butter, lecithin, and pharmaceutical grade sugar Thereafter drug is incorporated to above prepared chocolate base. Thus the prepared medicated chocolate is evaluated for appearance, moisture content, invitro drug release, blooming test, drug content & drug Excipients compatibility. In-vitro dissolution studies of formulated chocolate were performed by using 0.1N HCL as a dissolution media for Fexofenadine hydrochloride and using 0.1N Na0H as a dissolution media for Paracetamol. Among all six formulations the formulation six (F6) showed complete release of Fexofenadine hydrochloride with 94.52 at the end of 8 hours, Paracetamol with 98.11 at the end of 4 hours. The drug release from the chocolate shows First order release kinetics and diffusion mechanism.

Keywords: Medicated Chocolate, Pediatrics, Chocolate formulation.


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