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Abstract

“EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF CLERODENDRUM INFORTUNATUM LINN- IN RATS”

Anand Kale* and Yasmeen A Maniyar

ABSTRACT

Clerodendrum infortunatum Linn. (Verbenaceae) is an important and widely used medicinal plant. Though variously used in Ayurveda, Unani and Homeopathy system of medicine in case of ailments like diarrhoea, skin disorders, venereal and scrofulous complaints, wounds, post-natal complications, as antihelminthic, external applications on tumours, etc., the plant needs thorough investigation for its specific medicinal activity. This study evaluates the acute anti-inflammatory effect of the ethanolic extract of the leaves of Clerodendrum infortunatum Linn.(EECI) in experimental animals. Acute toxicity test was done following the OECD guidelines. Following the Phytochemical analysis of the plant extract for specific plant constituents, EECI (100mg/kg, 200mg/kg, and 400mg/kg body weight b.w. p.o) was evaluated for acute anti-inflammatory activity against the carrageenan induced rat paw edema and the effects compared with reference drug aspirin (300mg/kg b.w). In acute inflammation, EECI produced significant reduction (p<0.01) at 5th hr in all the doses.This may be attributed to the inhibition of prostaglandin synthesis, phospholipase A2, and TNF alpha. Clerodendrum infortunatum Linn. as a commercial source of anti-inflammatory drug should be subjected to further research.

Keywords: Clerodendrum infortunatum, Anti-inflammatory; Carrageenan; Paw edema.


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