WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF EFFERVESCENT TABLETS OF GLUCOSAMINE SULPHATE IN COMBINATION WITH IBUPROFEN AND VITAMIN- E FOR THE TREATMENT OF OSTEOARTHRITIS

Senthil Kumar Krishnan*, Chidananda B, Mohammed Gulzar Ahmed

ABSTRACT

Background and purpose of the study: Osteoarthritis (OA) is the most common joint disorder worldwide. Generally, oral dosage forms are used for the treatment of OA but they have some disadvantages like slow absorption and thus, onset of action is prolong. This can be overcome by administrating the drug in liquid form but, many APIs have limited level of stability in liquid form. Recently, effervescent drug delivery systems have started gaining popularity, because they are easy to administer and lead to better compliance. The aim of this study is to formulate effervescent tablet with sufficient mechanical integrity and to achieve faster disintegration in water. Method: They are intended to be dissolved or dispersed in water before use. The study was designed to assess the treatment for osteoarthritis by using combination of drugs such as Ibuprofen, Glucosamine and Vitamin E in an effective way. The dosage of Ibuprofen is reduced by addition of glucosamine sulphate (nutraceutical) on an assumption that the activity of ibuprofen may be enhanced by nutraceutical. The formulations were subjected to various evaluation tests. Results: All the formulations have shown good effervescence when placed in 100 ml of water. The resultant solution appeared clear indicating the solubility of ingredients in water. The friability and hardness of formulations are in the acceptable range. The Angle of Repose (θ), Hausner’s Ratio and Carr’s Compressibility Index (%) revealed that the formulations have good flow property. The solution time, CO2 and moisture content of all the formulations are in the acceptable range. Conclusion: All the results concluded that effervescent tablet preparation containing ibuprofen in combination with glucosamine sulphate and Vitamin-E can be formulated as marketed product for the treatment of osteoarthritis.

Keywords: Osteoarthritis, Effervescent, Ibuprofen, Glucosamine sulphate, Vitamin-E.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More