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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BILAYER BUCCAL TABLETS OF SALBUTAMOL SULPHATE

Bandi Bhavani*, Pavan Kumar Chadalawada, Rattaiah Gupta T

ABSTRACT

The objective of the present study was to design and evaluation of mucoadhesive bilayer buccal tablets salbutamol sulphate. since the drug has only 40% oral bioavailability, an attempt was made to develop mucoadhesive buccal tablets of salbutamol sulphate that could be applied to the buccal mucosa to release the drug unidirectionally in buccal cavity in order to decrease gastric irritation and avoid first pass effect for improvement in bioavailability to reduce the dose dumping frequency and to improve patient compliance. Salbutamol sulphate (SS) is a selective â2-adrenergic agonist which acts on â2- adrenoreceptor for the treatment of bronchospasm in conditions such as asthma and COPD. Formulation of tablet using various polymers for buccal delivery. Ethyl cellulose and magnesium stearate added to act as an impermeable backing layer which gives unidirectional buccal drug delivery.

Keywords: Mucoadhesive Bilayer Buccal Tablets, Salbutamol Sulphate, COPD, FT-IR, HPMC 3cps, HPMC 5cps, HPMC K4M, HPMC K15M, Mannitol, Carbopol 940 and Ethyl Cellulose.


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