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Abstract

IN-VITRO ANTI-DIABETIC EVALUATION OF TERMINALIA TOMENTOSA (Roxb). BARK

Meenakshi Sharma, *Richard Lobo, M.ManjunathSetty, Saleemulla Khan, Chandrashekhar K. S, C.S.Sreedhara

*Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104.

ABSTRACT

Diabetes mellitus is a disease caused by the imbalenced carbohydrate, fat and protein metabolism, caused due to either lack of insulin secretion or decreased sensitivity of the tissues to insulin, and is characterized by chronic raise in blood sugar levels termed as hyperglycaemia. The present work demonstrate the in vitro antidiabetic activity of Ethanolic and Aqueous extract of Terminalia tomentosa stem bark. The extracts were studied for their effect on inhibition of glycosylation of haemoglobin, and α-Amylase inhibition. Inhibition of glycosylation of haemoglobin and α- Amylase inhibition was found to be in a dose dependent manner. The results obtain confirms Terminalia tomentosa bark possesses antidiabetic activity. However, further studies on the extract and isolated constituents to be carried out on in vivo models and clinical trials for its effective utilization as therapeutic agents.

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