EFFECT OF VARIOUS PHYSIOCHEMICAL PARAMETERS ON ANTIMICROBIAL ACTIVITY OF ASPERGILLUS TERREUS
Harpreet Kaur and Daljit Singh Arora*
ABSTRACT
Aspergillus terreus isolated from soil showed broad spectrum
antimicrobial activity against different pathogenic microorganisms
including MRSA. Optimization of physiochemical parameters revealed
the optimum period of incubation for best antimicrobial activity to be 5
days. Shaking conditions were found to be better than static cultures.
The antimicrobial potential of the fungus was optimally best between
pH 5-7. Incubation temperature of 25°C found to be optimum for
growth as well as antimicrobial activity. Starch as a carbon source at a
concentration of 1% was best for antimicrobial production. Yeast
extract and soyabean meal (1%) were found to be the best nitrogen
rich sources for maximum biomass and antimicrobial activity.
Extraction with different organic solvents demonstrated ethyl acetate to
be the best for maximum antimicrobial activity against the entire microorganisms used in the
study.
Keywords: Antimicrobial, Aspergillus, optimization, Soil fungi.
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