WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF MICROBIAL TRIGGERED COLON SPECIFIC DELIVERY OF AZATHIOPRINE

Mahajan Ritu Priya, Sharma Ajay, Bhandari Govind, Mahajan S.C. *Mishra Pooja

ABSTRACT

Purpose: The Thioguanine derivative, Azathioprine (AZA) is a prodrug of 6-mercaptopurine that is further metabolized by various enzymes present in the liver and gut have proven efficacy in the treatment of inflammatory bowel disease (ulcerative colitis) in 2-2.5 mg/kg/day at 0,2 and 6 weeks than every 8 week and also may reduce the need for steroid treatment. In the present work sustained release formulation of azathioprine was developed with an objective to achieve colon specific drug delivery with reduced frequency of dosing, to minimize gastric side effect and thus to increase patient compliance. Method: The six different tablet formulations were prepared by direct compression method using Guar gum (GG), and xanthan gum (XG). Tablets are evaluated for their physicochemical properties and in vitro drug release studies. Biodegradability studies of guar and xanthan gum was carried out in presence of 4% w/v RCC and galactomannase enzyme (0.1 mg/ml.) by viscosity measurement using Brookfield viscometer and significant decrease in viscosity was found with 4% RCC after 24 h incubation. Result: In the rat caecal contents formulations shows enhanced drug release due to degradation of guar gum coat by colonic galactomannanase enzyme. The tablets containing guar (G1) released 70.07 %, at the end of 24th hour in rat caecal contents whereas, drug release from tablets containing a xanthan gum (X6) 79.06 % at the end of 24th hour. Conclusion: From the results of this study it appears that, the proposed microbial triggered matrix tablet of Optimized X6 formulation azathioprine (500 mg) conventional tablet with better control of drug release for targeted drug delivery. In addition developed colon-specific drug delivery system (CDDS) was relatively inexpensive and easy to manufacture using other techniques.

Keywords: Azathioprine, bacterially triggered, matrix tablets, colon targeting.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More