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Abstract

SPECTROPHOTOMETRIC QUANTITATIVE ESTIMATION OF HYDROCHOLOROTHIAZIDE AND LISINOPRIL IN BULK DRUGS AND PHARMACEUTICAL DOSAGE FORM

Nil Patel*, Prabhakara Prabhu, Sandeepsingh Walia

ABSTRACT

A simple, accurate, precise, economical and reproducible UV Spectrophotometric method has been developed for the simultaneous estimation of Hydrochlorothiazide and Lisinopril in bulk and in marketed combined tablet dosage form. The stock solutions were prepared in pH 1.2 buffer followed by further required dilutions with pH 1.2 buffer. Vierordt’s simultaneous equation method was developed and is validated statistically as per ICH guidelines. The absorbance maxima of Hydrochlorothiazide and Lisinopril were found to be 269.8nm & 209.4nm respectively. Linearity was observed by linear regression equation method for both drugs in different concentration range. The Correlation coefficient of these drugs was found to be close to 1.00, indicating good linearity. The % R.S.D. were found to be less than 2 % as required by ICH guidelines, which indicates the validity of methods. Statistical analysis proves that the proposed method can be effectively applied for the simultaneous estimation of these two drugs in bulk & combined dosage forms.

Keywords: Hydrochlorothiazide, Lisinopril, Vierordt’s simultaneous equation method, etc.


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