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Abstract

INVESTIGATION OF RELATIONSHIP BETWEEN SERUM CREACTIVE PROTEIN (CRP) LEVEL AND THE RATE OF MICROBIAL INFECTION IN “COPD” PATIENT

S. Ahmed John* and S. Vasuki Srinivasan

ABSTRACT

The present study aimed to investigate the relationship between the serum C-reactive protein (CRP) level and the rate of microbial infection in chronic obstructive pulmonary disease (COPD) patient. From November 2012 to October 2013, 138 serum and respiratory sample collected from stable COPD patient of private hospital south Tamilnadu, India. Serum CRP level measured by Immunoturbidity method and sputum sample were collected for culture. Among 138, the mean value of CRP in culture positive group (75 subject ) was 148.94 (range : 50 mg/L to 250 mg /L) and SD 56, while in culture negative group (63 subjects) the mean value was 11.22 mg/L ( range: 6- 20 in 40 subject) and SD was 4.64 and the mean value in 23 subject was 36.69 mg/L (range: >20 – 50mg/L in 23 subject) and SD was 9.20 in culture negative group. Statistical analysis, the mean value of CRP was significantly higher in culture positive patient (CRP level >50mg/L). In culture positive group the following organism were isolated with 54 % (14 Klebsiella (10%),13 Pseudomonas (9%), 1 Acinetobacter (1%), 3 E.coli (2%), 25 Haemophilus influenza(18%), 2 Staphylococcus aureus (1%), 3 Streptococcus pneumonia (2%), 11 candida species (8%), 3 Filamentous fungi (2%) and 63 recorded culture negative with 46% and 8 TB positive with 5%. The predominant bacterial isolate was Haemophilus influenza. The circulating level of CRP significantly elevated in culture positive stable COPD patient than culture negative patient. CRP value from > 6 to 50, in culture negative group those were had symptoms of chronic cough, chills and mild grade fever. It revealed, in COPD patient the CRP value was above the normal range ( >6 mg/L) even if culture negative cases it may be due to viral or intra nuclear infection.

Keywords: Chronic Obstructive Pulmonary Disease, C-reactive protein, Bacterial infection.


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