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Abstract

ACUTE TOXICITY STUDY AND ANTIDIABETIC ACTIVITY OF POLY HERBAL HYDRO ETHANOLIC EXTRACTS [PHE-A, B, C, D AND E] OF INDIVIDUAL PLANTS IN DIFFERENT RATIOS

Anita Singh* and Anil Waldia

ABSTRACT

The present study was an attempt to investigate the effect of polyherbal
extract on acute toxicity and streptozotocin induced diabetes in albino
rats. The polyherbal extracts were obtained from the plants of Berberis
aristata, Eleusine coracana, Abelmoschus esculentus, Eugenia
jambolana, Tinospora cordifolia crude drugs in different ratios. The
blood glucose level was measured on 0th, 7th, 14th and 21th day and
body weight, lipid profile ware measured at the end of the study i.e.
after 21days of treatment. Polyherbal extract and glibenclamide show a
significant (p<0.001) reduction in blood glucose level, lipid profile,
where as both the treatments increased body weight, liver glycogen
content and antioxidant status when compared to the diabetic control. It has been concluded
that Polyherbal extract posses antidiabetic activity in the streptozotocin induced diabetic
model.

Keywords: Antidiabetic, Berberis aristata, Eleusine coracana, Abelmoschus esculentus, Eugenia jambolana, Tinospora cordifolia and streptozotocin.


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