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Abstract

HEPATOPROTECTIVE ACTIVITY OF AQUEOUS ETHANOLIC EXTRACT OF AERIAL PARTS OF BARLERIA GIBSONI ON PCTINDUCED HEPATOTOXICITY IN RATS

Lakshman Kumar D*, Sravani M, Dr.Venkatesh P, Dr. Hepcy Kala Rani D, Dr. Purushothaman M, Sucharitha P A M

ABSTRACT

Barleria gibsoni belonging to the family Acanthaceae is commonly
known as Neel Koranti. Several species of Barleria are reported for
treatment of inflammation associated diseases like Gout, Rheumatism
and swelling etc. So, the present work has been taken for
phytochemical screening and to investigate Hepatoprotective activity.
Natural remedies from medicinal plants are considered to be effective
and safe alternative treatment for liver injury. The present study was
conducted to evaluate the Hepatoprotective activity of aqueous
ethanolic [30:70] extract of aerial parts of Barleria gibsoni
Dalz.(AEEBG) in albino wistar rats. The study was conducted using
the popular inducing agent Paracetamol (PCT) in Carboxy methyl
cellulose (CMC) and silymarin was used as reference standard in the
respective model to treat for 21 days. The effect was estimated by measuring the enzymatic
levels. Phytochemical screening of AEEBG revealed the presence of phytocontituents like
carbohydrates, phenolic compounds, tannins and flavonoids. The aqueous ethanolic extract of
aerial parts of Barleria gibsoni Dalz. has shown very significant hepato protection against
PCT- induced hepatotoxicity in albino wistar rats.

Keywords: Barleria gibsoni, Hepato protective activity, Paracetamol, Carboxy methyl cellulose, silymarin.


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