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Abstract

CORRELATION BETWEEN CORTISOL; GLUCOSE LEVELS, INSULIN RESISTANCE AND BODY MASS INDEX IN OVERT HYPOTHYROID NON-DIABETIC MEN PATIENTS

*Ali Shalash Sultan and Dhelal Abdul Khaliq Jumma

ABSTRACT

The present study was conducted on 24 hypothyroid non -diabetic men patients group aged 20-60 years and 24 control group aged 20-56 years in Baghdad province at the specialist center of Endocrine and Diabetic diseases to evaluate the relationship between cortisol, insulin, glucose, glycated haemoglobin, insulin resistance, body mass index (BMI) and their correlations among non–diabetic overt hypothyroid men patients. The results in hypothyroid patients group showed highly significant (P<0.01) increase in the level of TSH(43.74 ± 3.61mμ/L);while T4 level (48.59±0.98 nmol/L) decrease significantly(P<0.01). T3 nmol/l levels (1.31 ± 0.14) in hypothyroid group were not significant (p≥0.05) in comparsion with control group(1.52 ±0.083). Cortisol (274.08± 9.37ng/ml); insulin(15.13±1.14 μU/ml) increased highly significant in patients group. Fasting blood glucose (F.B.G) and HbA1C% had shown non differences. Insulin resistance and BMI increased highly significant in patients group. The results in patients group showed the following correlations; cortisol had positive correlation (0.65)with TSH and negative correlation(-0.32) with T4.Insulin resistance showed positive correlation with FBG(0.32) and BMI(0.33). BMI showed positive(0.39)correlation with increasing TSH level and negative correlation with T4(-0.36)and no correlation with T3. We concluded from our present study that such an increase in level of cortisol in the non-diabetic overt hypothyroid men patients with increasing TSH levels had contribute to elevate insulin level with increasing insulin resistance that Insulin resistance associated with distribution of body fat subsequently leading to an increase of body mass index(BMI) among hypothyroid patients through most the positive correlations.

Keywords: glycated haemoglobin, Endocrine, Diabetic and TSH.


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