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Abstract

GENETIC POLYMORPHISM OF MULTIDRUG RESISTANCE GENE (MDR1) IN ASSOCIATION WITH BREAST CANCER OF SUDANESE PATIENTS

Mayada Elkhalifa Ali*, Salaheldein G Elzaki and Elshich Elobid

ABSTRACT

Objective This study was done in breast cancer of Sudanese patient to show the frequency of multidrug Resistance gene (MDR1) genetic polymorphism and association between this genetic polymorphism and treatment unresponsiveness. also to determine genotyping frequency of this patients. Method Seventy seven patients of breast cancer were reurited in this study of whom fifty were successfully genotyped where the remaining twenty seven were not genotyped and therefore excluded from the study, all the patients was taken from Radiation and Isotopes Centre Khartoum (RICK), and (MDR1) gene was amplified using polymerase chain reaction (PCR) techniques then the gene was digested using Sau3A1 restriction enzyme. Results 44% were CC (wild type alleles), 14% were CT (heterozygous), and 42% were TT (Homozygous). Patients with (CC) genotype normal allele have larger survival time than mutant one. Conclusion patients with (CT) or (TT) mutant alleles administered highly numbers of doses for long duration of therapy this good indication for chemotherapeutic treatment unresponsiveness. Patients with mutant allele which were untreated till the time of study have larger susceptibility to chemotherapeutic resistance.

Keywords: Multidrug Resistance gene (MDR1), Genetic polymorphism, Genotyping, Polymerase chain reaction (PCR).


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