WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PRODUCTION OF LOVASTATIN BY ASPERGILLUS FISCHERI NCIM 509 USING BLACKGRAM HUSK UNDER SOLID STATE FERMENTATION

D. Prasanna Latha* and K. P. J. Hemalatha

ABSTRACT

Production of lovastatin was carried out by Aspergillus fischeri NCIM- 509 using agro-industrial residue blackgram husk, as substrate under solid state fermentation. Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone marrow, neovascularization, vascular tone, and arterial pressure. Process parameters like Incubation time (5-days), Temperature (28oC), Moisture content (60%), Inoculum age (4 days), Inoculum volume (40% v/w),pH of the medium(6.0), carbon source (1.5% Lactose) and nitrogen source(2.0% Ammonium Sulphate) were optimized and gave an overall yield of 9.2 mg/gds of lovastatin after optimization.

Keywords: Lovastatin, Aspergillus fischeri, blackgram husk, Solid state fermentation, Process parameters, Optimization.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More